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Results of radiotherapy with, or without, salvage surgery versus combined surgery and radiotherapy in advanced carcinoma of the hypopharynx

Published online by Cambridge University Press:  08 March 2006

S. Bahadur ,
A. Thakar ,
B. K. Mohanti  and
P. Lal
S. Bahadur
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
A. Thakar
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
B. K. Mohanti
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
P. Lal
Affiliation:
Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
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Abstract

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There is considerable controversy surrounding the optimum treatment of advanced hypopharyngeal cancers. Curative radiotherapy with surgical salvage in reserve is an accepted protocol as is also a combined treatment of surgery and radiotherapy. The present study is a retrospective analysis of the survival results of 195 cases treated in a single centre. The combined surgery and radiotherapy group comprised a greater number of pyriform fossa and post-cricoid tumours whereas, the curative radiotherapy group had a higher proportion of posterior pharyngeal wall tumours. Actuarial two-year disease-free survival rates were significantly better with combined treatment when results of stage III and IV lesions (164 patients) of all sites are taken together, as compared to those obtained with curative radiotherapy without salvage (p = 0.000) or radiotherapy with surgical salvage for residual/recurrent tumours (p = 0.0021).

Keywords

Hypopharyngeal NeoplasmsSurgical ProceduresOperativeRadiotherapyAdjuvantRadiotherapy
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 116 , Issue 1 , January 2002 , pp. 29 - 32
Copyright
© Royal Society of Medicine Press Limited 2002