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Reinke's oedema, hormones and hormone replacement therapy

Published online by Cambridge University Press:  23 May 2006

A Tsikoudas ,
X Kochillas  and
G Vernham
A Tsikoudas
Affiliation:
St John's Hospital and the Western General Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Edinburgh, Scotland, UK
X Kochillas
Affiliation:
St John's Hospital and the Western General Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Edinburgh, Scotland, UK
G Vernham
Affiliation:
St John's Hospital and the Western General Hospital, Department of Otorhinolaryngology, Head and Neck Surgery, Edinburgh, Scotland, UK
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Abstract

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Objective: To study the implications of hormone replacement therapy (HRT) treatment in the pathogenesis of Reinke's oedema (via a possible pseudo-hypothyroidism effect), and also to study why the disease affects a predominantly post-menopausal female population.

Design: Prospective case series study.

Setting: Two teaching hospitals and two district general hospitals in Scotland, UK.

Subjects: Thirty-three patients diagnosed with Reinke's oedema who presented in the out-patient department before or after treatment.

Results: Thyroid function tests were normal in all but two cases. Only three patients were receiving HRT treatment.

Conclusions: The study produced no evidence to support a relationship between HRT treatment and the pathogenesis of Reinke's oedema; this supports previous studies which concluded that thyroid function was not related to the development of Reinke's oedema. Some new ideas regarding hormonal factors in Reinke's oedema are discussed.

Keywords

LarynxOedemaHormone Replacement TherapyPost-MenopausalThyroid Function Tests
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 10 , October 2006 , pp. 849 - 852
Copyright
2006 JLO (1984) Limited