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Olfactory dysfunction amongst children and adolescents with laboratory confirmed coronavirus disease 2019: a systematic review

Part of: JLO Coronavirus Collection

Published online by Cambridge University Press:  02 September 2021

J Saniasiaya ,
J Kulasegarah  and
P Narayanan
J Saniasiaya*
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
J Kulasegarah
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
P Narayanan
Affiliation:
Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Malaysia
*
Author for correspondence: Dr Jeyasakthy Saniasiaya, Department of Otorhinolaryngology, Faculty of Medicine, University of Malaya, Jalan Universiti, 50603 Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia E-mail: shakthy_18@yahoo.com
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Abstract

Background

Despite the rapidly emerging reports of olfactory dysfunction amongst adult patients with coronavirus disease 2019, cases involving children and adolescents are scarcely reported. The literature was reviewed to elucidate olfactory dysfunction amongst children and adolescents with coronavirus disease 2019.

Methods

A search of the literature published from 1 December 2019 to 30 April 2021 was conducted using four databases, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The search was performed over one month (May 2021).

Results

Only 9 articles were identified, with a total of 316 laboratory confirmed coronavirus disease 2019 positive children and adolescents, of whom 156 reported olfactory dysfunction. Four studies reported olfactory dysfunction based on subjective tests; four studies carried out objective assessment. Most studies reported on olfaction recovery.

Conclusion

The literature review revealed an olfactory dysfunction rate of 49 per cent amongst children and adolescents with coronavirus disease 2019. Persistence of olfactory dysfunction was reported in 7.1 per cent of the patients. Further studies involving objective measures need to be carried out in children and adolescents with coronavirus disease 2019.

Keywords

CoronavirusCOVID-19SmellOlfactory ImpairmentChildrenAdolescentsPediatricsReview
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 11 , November 2021 , pp. 953 - 957
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

Introduction

Since the emergence of coronavirus disease 2019 (Covid-19) in December 2019, various novel presentations have burgeoned. Nevertheless, early detection of Covid-19 patients remains the key to curbing community spread whilst controlling the raging pandemic. Ever since new-onset olfactory dysfunction became one of the primary screening symptoms, awareness of this entity has increased. Yet, most of the reported cases involve adult patients. Additionally, anosmia has been regarded as a highly specific and moderately sensitive screening symptom for Covid-19 infection in adults.Reference Wee, Chan, Teo, Cherng, Thien and Wong1

Children and adolescents are not excluded from being afflicted with Covid-19, although early reports suggest that they have milder symptoms and are less likely to be hospitalised than adults. Yet, children and adolescents who are asymptomatic may play a role in community transmission of the virus. This review aimed to cover the current literature available on the prevalence of olfactory dysfunction amongst children and adolescents with Covid-19.

Materials and methods

We performed a comprehensive search using four databases, namely PubMed®, Embase (Elsevier, Amsterdam, the Netherlands), Scopus (Elsevier) and Google Scholar, of literature published between 1 December 2019 and 30 April 2021. The search was carried out over a one-month period (May 2021) in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelinesReference Moher, Liberati, Tetzlaff, Altman and ;2 and the Cochrane Handbook for Systematic Reviews of Interventions.Reference Higgins and Green3 Published or in-press peer-reviewed cross-sectional case series and case reports providing information on olfactory disturbance amongst children who were positive for Covid-19 were included.

The following search terms (key words) were either used individually or combined: ‘Coronavirus’, ‘COVID-19’, ‘SARS-CoV-2’, ‘olfactory’, ‘children’, ‘adolescents’, ‘paediatric’, ‘pediatric’, ‘smell’, ‘olfaction’, ’anosmia’, ‘hyposmia’, ‘dysosmia’, ‘parosmia’ and ‘phantosmia’. In addition, the reference lists of all included articles were explored to identify articles not found by the electronic searches. Complete details of the search strategy are shown in Figure 1. Duplicate studies were excluded using EndNote™ X10 reference management software.

Fig. 1. Flow diagram of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) for the systematic literature search.

Studies were considered eligible for inclusion if: (1) they were case reports, case series or observational studies; (2) patients included had laboratory confirmed Covid-19 and were younger than 18 years of age; and (3) they included patients with new-onset olfactory dysfunction related to Covid-19. Additionally, correspondence letters or letters to the editor that fulfilled the mentioned eligibility criteria were included. Studies were excluded if: (1) patients included were aged above 18 years; (2) Covid-19 was not diagnosed via a laboratory confirmed method; (3) patients included did not have olfactory dysfunction; (4) patients included had olfactory dysfunction prior to Covid-19; (5) they were an abstract-only study; and (6) articles were written in languages other than English.

The titles and abstracts of each article identified in the search were assessed for eligibility based on the inclusion criteria by two independent reviewers (JS and JK). Full-text articles were analysed individually. Any discrepancies during the selection process were resolved by discussion and consensus.

Two reviewers (JS and JK) extracted the data independently with a standardised data collection form, which included: (1) basic information; (2) demographic information (age and gender); (3) presence of olfactory and/or gustatory dysfunction; (4) other Covid-19-related symptoms; (5) subjective and/or objective assessment of the olfactory or gustatory dysfunction; and (6) outcome of olfactory and/or gustatory symptoms. If data were missing or reported in an unusable method, the study was excluded. After scrutiny by the panel members, nine articles were selected based on our objective and selection criteria.

Results

A total of nine articles, originally published online between 1 December 2019 and 30 April 2021, that fulfilled the selection criteria were included in the review (Table 1).Reference Bernaola Abraira, Bartha De Las Peñas, López-Araujo, Escudero Diez, Rodríguez Del Río and Morales-Cabeza4–Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 The articles included three retrospective studies,Reference Bernaola Abraira, Bartha De Las Peñas, López-Araujo, Escudero Diez, Rodríguez Del Río and Morales-Cabeza4,Reference Concheiro-Guisan, Fiel-Ozores, Novoa-Carballal, González-Duran, Portugués de la Red and Martínez-Reglero5,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 three case reports,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Maniaci, Iannella, Vicini, Pavone, Nunnari and Falsaperla9,Reference Marhaeni, Wijaya, Kusumaningtyas and Mapianto10 two prospective studiesReference Kumar, Kahlon, Jain, Kaur, Singh and Pandey7,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 and one case series.Reference Mak, Chung, Wong, Shek and Kwan8 Patients were from Asia in five articles,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6–Reference Mak, Chung, Wong, Shek and Kwan8,Reference Marhaeni, Wijaya, Kusumaningtyas and Mapianto10,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 Europe in four articlesReference Bernaola Abraira, Bartha De Las Peñas, López-Araujo, Escudero Diez, Rodríguez Del Río and Morales-Cabeza4,Reference Concheiro-Guisan, Fiel-Ozores, Novoa-Carballal, González-Duran, Portugués de la Red and Martínez-Reglero5,Reference Maniaci, Iannella, Vicini, Pavone, Nunnari and Falsaperla9,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 and Russia in one article.Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 One study included patients from three countries: China, Germany and France.Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 The total number of patients included in this review is 316, of whom a total of 156 had olfactory dysfunction (49 per cent). The total number of patients in each article ranged from 1 to 68. The age and gender of the patients included were not reported in most studies.

Table 1. Summary of findings for included studies

*Follow-up data were not obtained for one child in the German cohort. Covid-19 = coronavirus disease 2019; MIS-C = coronavirus disease 2019 related Multisystem Inflammatory Syndrome in Children; RT-PCR = reverse transcription polymerase chain reaction; NR = not reported; F = females; M = males; ID = identification; VAS = visual analogue score; IV = intravenous; SNOT-22 = Sino-Nasal Outcome Test-22

All patients included were diagnosed with Covid-19 on the basis of laboratory based reverse transcription polymerase chain reaction testing. Only five studies reported on the mode of olfactory assessment: objective evaluation was carried out in four studiesReference Concheiro-Guisan, Fiel-Ozores, Novoa-Carballal, González-Duran, Portugués de la Red and Martínez-Reglero5,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 and subjective assessment in four studies.Reference Bernaola Abraira, Bartha De Las Peñas, López-Araujo, Escudero Diez, Rodríguez Del Río and Morales-Cabeza4,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 The psychophysical assessment was performed using an odour identification test in four articles.Reference Concheiro-Guisan, Fiel-Ozores, Novoa-Carballal, González-Duran, Portugués de la Red and Martínez-Reglero5,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 Kasuga et al. used the Alinamin® test, an intravenous olfaction test.Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6 Questionnaire evaluation was used in three studies,Reference Bernaola Abraira, Bartha De Las Peñas, López-Araujo, Escudero Diez, Rodríguez Del Río and Morales-Cabeza4,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 and a visual analogue scale was used in two studies.Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11

None of the included studies mentioned distortion or alteration of smell such as parosmia or phantosmia. In addition, no specific treatment for olfactory dysfunction was mentioned. The persistence of olfactory dysfunction was reported in 11 patients (7.1 per cent).Reference Kumar, Kahlon, Jain, Kaur, Singh and Pandey7–Reference Maniaci, Iannella, Vicini, Pavone, Nunnari and Falsaperla9,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 None of the children included in this review developed Covid-19-associated multisystem inflammatory syndrome.

Discussion

Smell or olfaction is regarded as the primordial organ of sense, and has been traditionally associated with safety, nutrition and the sensation of pleasure, as well as general quality of life.Reference Pinto13 Olfaction plays an important role in children, as smell is important in attaining a balanced diet for proper nutrition.Reference Ruijschop, Boelrijk, de Graaf and Westerterp-Plantenga14 The prevalence of olfactory dysfunction in the general population has been reported to be nearly 6 per cent,Reference Brämerson, Johansson, Ek, Nordin and Bende15 and the prevalence in children is believed to be lower,Reference Deems, Doty, Settle, Moore-Gillon, Shaman and Mester16 although no concrete data exist to date.Reference Schriever, Agosin, Altundag, Avni, Cao Van and Cornejo17 Olfactory dysfunction in children has been linked to a myriad of conditions, including autism,Reference Bennetto, Kuschner and Hyman18 attention-deficit disorder,Reference Karsz, Vance, Anderson, Brann, Wood and Pantelis19 head traumaReference Roberts and Simcox20 and cleft palate.Reference Richman, Sheehe, McCanty, Vespasiano, Post and Guzi21

Based on a recent meta-analysis of 83 studies, the prevalence of olfactory dysfunction in individuals with Covid-19 was reported to be 47.85 per cent.Reference Saniasiaya, Islam and Abdullah22 Yet, the prevalence of olfactory dysfunction in children with Covid-19 has been postulated by experts to be much lower.Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11 This conjecture is based on several factors, including the gene expression of angiotensin-converting enzyme 2 (ACE-2) (responsible for binding with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the nasal mucosa), which is age-dependent and lower in children.Reference Bunyavanich, Do and Vicencio23 In addition, the immaturity of immunological development in children is considered one of the leading factors behind the lower prevalence of olfactory dysfunction in children.Reference Maniaci, Iannella, Vicini, Pavone, Nunnari and Falsaperla9 Interestingly, in our review, approximately 50 per cent of children and adolescents with Covid-19 developed olfactory dysfunction. We believe that the number of children and adolescents with olfactory dysfunction is higher than expected when a proper olfaction assessment is carried out.

Olfactory dysfunction can be detected through various objective assessment tools, or subjectively by questionnaires or history-taking. However, the challenge in detecting olfactory dysfunction in children lies in the inconsistency of assessment tools as well as the limited availability of age-appropriate paediatric reference ranges.Reference Calvo-Henríquez, Chiesa-Estomba, Martinez-Capoccioni, Lechien, Mota-Rojas and Mayo-Yáñez24

Objective assessment tools available to assess olfactory dysfunction in children include: odour detection, which requires odour to be detected; odour identification, which requires odour to be recognised; and odour discrimination, which requires the ability to differentiate one odour from another. The odour detection threshold assesses odorants at different concentrations, whereas cortical processing of the olfaction is assessed via electrophysiological measurements and olfactory evoked potentials.Reference Calvo-Henríquez, Chiesa-Estomba, Martinez-Capoccioni, Lechien, Mota-Rojas and Mayo-Yáñez24 The odour identification test is the most favoured test for olfactory dysfunction in children. Yet, the reliability of odour identification tasks in children has been challenged by many authors, as identifying the odour has been linked to memory, attention and linguistic processing rather than the odour itself.Reference Thomas-Danguin, Rouby, Sicard, Vigouroux, Farget and Johanson25 In this review, four studies reported olfactory dysfunction based on objective assessment,Reference Concheiro-Guisan, Fiel-Ozores, Novoa-Carballal, González-Duran, Portugués de la Red and Martínez-Reglero5,Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6,Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 and all used odour identification tests. As part of their olfactory dysfunction assessment, Kasuga et al. utilised the Alinamin test, which involves the intravenous administration of propyl disulphide; this is followed by determination of latency, the time between the initiation of the injection and recognition of the odour (garlic), as well as duration, and the time between recognition and disappearance of the odour.Reference Kasuga, Nishimura, Go, Nakazaki, Shimizu and Kanezawa6

Subjective assessment tools for olfactory dysfunction available for children include questionnaires. However, no validated questionnaires that assess olfactory dysfunction in children are available to date. Additionally, objective or psychophysical testing was found to be more sensitive than subjective surveys when performed in the same study.Reference Qiu, Cui, Hautefort, Haehner, Zhao and Yao11,Reference Rusetsky, Meytel, Mokoyan, Fisenko, Babayan and Malyavina12 This may be attributed to the fact that olfactory dysfunction is only recognised when it results in significant loss of smell, such as anosmia, rather than hyposmia.Reference Saniasiaya, Islam and Abdullah22

Olfactory dysfunction amongst Covid-19 patients has been reported to be short-lived in children, as previously reported in adults.Reference Ramasamy, Saniasiaya and Abdul Gani26 Rapid recovery was reported in most of the included studies. However, olfactory dysfunction persisted in 11 (7.1 per cent) of the patients included in this review. Partial or complete olfaction recovery has been reported in most studies involving adult patients,Reference Saniasiaya, Islam and Abdullah22 although it may take several monthsReference Hummel, Whitcroft, Andrews, Altundag, Cinghi and Costanzo27 because of the longer time needed for regeneration of the damaged olfactory neurons.

None of the studies included in this review reported on specific treatment directed to olfactory dysfunction. Both oral as well as nasal steroids, which are routinely used in treating anosmia, are avoided because of the risk of further suppressing the immune system in Covid-19 patients.

Although no published paediatric olfactory dysfunction screening tools have been validated for use in children with Covid-19, simple questions regarding changes in smell, either a decrease, alteration, distortion, or complete loss of smell, ought to be included during screening. Olfactory dysfunction symptoms reported by children warrant immediate investigation to rule out Covid-19. In parallel, it has been suggested that olfactory education should be included hand-in-hand with other health promotion teaching regarding Covid-19, such as handwashing techniques, within playschools, nurseries and schools.

  • • Olfactory dysfunction has been identified as a notable clinical manifestation of coronavirus disease 2019 (Covid-19) in adults and children

  • • This review indicates that olfactory dysfunction affects 49 per cent of children and adolescents with Covid-19

  • • Prevalence may be higher as there is no definite investigation method for olfactory dysfunction in children, especially toddlers

  • • The recovery rate for olfactory dysfunction is high

  • • Olfactory dysfunction persistence after one month requires follow up and olfactory retraining therapy

Conclusion

Based on our review, the prevalence of olfactory dysfunction was found to be 49 per cent among children and adolescents with Covid-19. Early recovery was documented in most studies, although the persistence of symptoms was noted in 7.1 per cent of patients.

Acknowledgement

We would like to acknowledge all involved in this study.

Competing interests

None declared

Footnotes

Dr J Saniasiaya takes responsibility for the integrity of the content of the paper

References

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Figure 0

Fig. 1. Flow diagram of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (‘PRISMA’) for the systematic literature search.

Figure 1

Table 1. Summary of findings for included studies