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Impact of antibiotics on pathogens associated with otitis media with effusion

Published online by Cambridge University Press:  07 April 2006

Yukiko Hamamoto ,
Yukako Gotoh ,
Yoshimi Nakajo ,
Satoko Shimoya ,
Chikako Kayama ,
Shingo Hasegawa  and
Ken-Ichi Nibu
Yukiko Hamamoto
Affiliation:
the Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
Yukako Gotoh
Affiliation:
Kohnan General Hospital, Kobe, Japan.
Yoshimi Nakajo
Affiliation:
Kohnan General Hospital, Kobe, Japan.
Satoko Shimoya
Affiliation:
Kohnan General Hospital, Kobe, Japan.
Chikako Kayama
Affiliation:
Kohnan General Hospital, Kobe, Japan.
Shingo Hasegawa
Affiliation:
Kohnan General Hospital, Kobe, Japan.
Ken-Ichi Nibu
Affiliation:
the Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan.
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Abstract

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Objective: To further understand the roles of bacteria and antibiotics in the development of otitis media with effusion (OME).

Methods: Samples of middle-ear effusion (MEE) were collected during the placement of ventilation tubes to treat chronic OME. Children with acute otitis media within the past three months were excluded from this study. We used polymerase chain reaction (PCR) to detect pathogens and to test the susceptibility of Streptococcus pneumoniae to penicillin.

Results: Among MEE samples from 52 children, PCR detected bacterial DNA in 32 per cent (24/75) of them. S. pneumoniae was detected more frequently in middle ears that required ventilation tube insertion at least twice compared with those requiring ventilation tube insertion only once (5/15 versus 4/60; p = 0.013). Higher levels of S. pneumoniae were detected in MEE from children with, than without, a long history of antibiotic administration (7/10 versus 2/14; p = 0.0187). The pbp genes of all isolated S. pneumoniae contained mutations.

Conclusions: Long exposure to antibiotics might significantly influence the bacterial genome in MEE.

Keywords

Otitis Media With EffusionBacteriaPolymerase Chain ReactionAntibiotics
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 119 , Issue 11 , November 2005 , pp. 862 - 865
Copyright
© 2005 Royal Society of Medicine Press