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Helicobacter pylori infection and chronic, persistent cough: is there an association?

Published online by Cambridge University Press:  13 February 2007

M Talaat ,
M S Gad ,
E A Magdy ,
S M Aggag  and
Y A Nour
M Talaat
Affiliation:
Department of Otorhinolaryngology – Head & Neck Surgery, Alexandria University, Alexandria, Egypt
M S Gad
Affiliation:
Department of Internal Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt
E A Magdy
Affiliation:
Department of Otorhinolaryngology – Head & Neck Surgery, Alexandria University, Alexandria, Egypt
S M Aggag
Affiliation:
Department of Clinical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Y A Nour
Affiliation:
Department of Otorhinolaryngology – Head & Neck Surgery, Alexandria University, Alexandria, Egypt
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Abstract

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Introduction: Chronic, persistent cough is a common clinical problem, the cause of which sometimes remains unidentifiable.

Aims: To study a potential association between Helicobacter pylori infection and chronic, persistent cough.

Materials and methods: A clinical observational study with symptom analysis, including 162 patients whose main presenting complaint was chronic, persistent cough of unidentifiable cause (study group) and 42 patients with chronic, non-specific laryngopharyngeal manifestations not including chronic cough (control group).

Results: Active H pylori infection was present in 86.4 per cent (140/162) of patients in the chronic cough group, as opposed to 45.2 per cent (19/42) of the control group, as confirmed by detection of H pylori antigen in stool specimens. This difference was statistically significant (p<0.001). There was a significant improvement of the chronic cough of 75.4 per cent (98/130) of patients after successful H pylori eradication using appropriate medical therapy (p<0.001).

Conclusions: Helicobacter pylori infection may lead to laryngopharyngeal irritation, with several clinical manifestations including chronic, persistent cough. However, the exact mechanism of this requires further research.

Keywords

Helicobacter PyloriCoughPharynxLarynx
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 121 , Issue 10 , October 2007 , pp. 962 - 967
Copyright
2007 JLO (1984) Limited