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Amphotericin B nasal spray has no effect on nasal polyps

Published online by Cambridge University Press:  11 September 2006

A Helbling ,
A Baumann ,
C Hänni  and
M Caversaccio
A Helbling
Affiliation:
Division of Allergology, Department of Rheumatology and Clinical Immunology/Allergology, University Hospital (Inselspital), Bern, Switzerland
A Baumann
Affiliation:
Department of ENT and Head and Neck Surgery, Institute of Pharmacy, University Hospital (Inselspital), Bern, Switzerland
C Hänni
Affiliation:
Department of Oncology, Institute of Pharmacy, University Hospital (Inselspital), Bern, Switzerland
M Caversaccio
Affiliation:
Department of ENT and Head and Neck Surgery, Institute of Pharmacy, University Hospital (Inselspital), Bern, Switzerland
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Abstract

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Nasal polyps and chronic rhinosinusitis are the products of an inflammatory process. Recently, fungal involvement has been thought to stimulate the development of polyps, and administration of antifungal agents was therefore considered a potential treatment. Several studies have been published indicating amphotericin B as an effective treatment for nasal polyps and chronic rhinosinusitis. The aim of our investigation was to evaluate the efficacy of intranasal applied amphotericin B on the growth of nasal polyps in a three-month, prospective, open trial. Our results show that nasal amphotericin B spray is not effective for nasal polyps and may even cause deterioration.

Keywords

Nasal PolypsAmphotericin BAntifungal Agents
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 120 , Issue 12 , December 2006 , pp. 1023 - 1025
Copyright
2006 JLO (1984) Limited