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A comparative study of toxocariasis and allergic asthma in murine models

Published online by Cambridge University Press:  07 February 2017

E. Pinelli ,
J. Dormans ,
M. Fonville  and
J. van der Giessen
E. Pinelli*
Affiliation:
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
J. Dormans
Affiliation:
Laboratory for Pathology and Immunobiology, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
M. Fonville
Affiliation:
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
J. van der Giessen
Affiliation:
Microbiological Laboratory for Health Protection, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
*
*Fax: +31 30 2744418 E-mail: elena.pinelli@rivm.nl
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Abstract

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Histopathology of the lung and total IgE in serum were compared in toxocariasis and allergic asthma murine models using BALB/c and C57BL/6 mice. Infection with Toxocara canis resulted in both strains of mice in marked histological changes and increased levels of total serum IgE. The ovalbumin (OVA) sensitization/challenge treatment for the induction of allergic asthma resulted in similar histological changes in BALB/c and, to a less extent, in C57BL/6 mice. Serum IgE levels of OVA-treated C57BL/6 mice were low. Histological changes observed included perivascular infiltration with eosinophils and mononuclear cells, peribronchiolitis, alveolitis and mucus production. Although these changes in addition to increased IgE production did occur in T. canis-infected C57BL/6 mice they were more pronounced in BALB/c mice. Thus, BALB/c mice appear to be the most appropriate strain of mice to perform studies on the possible connection between infection with T. canis and allergic asthma.

Type
Research Article
Information
Journal of Helminthology , Volume 75 , Issue 2 , June 2001 , pp. 137 - 140
Copyright
Copyright © Cambridge University Press 2001