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Structure–function analysis and the molecular origins of anti-DNA antibodies in systemic lupus erythematosus

Published online by Cambridge University Press:  11 February 2004

Jatinderpal Kalsi ,
Chelliah T. Ravirajan ,
Anisur Rahman  and
David A. Isenberg
Jatinderpal Kalsi
Affiliation:
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
Chelliah T. Ravirajan
Affiliation:
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
Anisur Rahman
Affiliation:
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
David A. Isenberg
Affiliation:
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
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Abstract

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Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE or ‘lupus’) develop a wide variety of clinical and serological manifestations including the presence of antibodies to double-stranded DNA (dsDNA), which are often diagnostic and potentially pathogenic. In this review, we have examined the links between the structure and function of anti-dsDNA antibodies, emphasising their clinical associations. We have also reviewed studies involving animal models, the analysis of human antibody sequences and studies of, and using, computer modelling and crystal structure.

Keywords

systemic lupus erythematosusSLEstructure function analysisanti DNA antibodiesdsDNAssDNAlupusautoimmunitymolecular mimicryantibodyrecombinant immunoglobulin
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 1 , Issue 7 , 16 February 1999 , pp. 1 - 28
Copyright
© Cambridge University Press 1999