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pathways to improving skin regeneration

Published online by Cambridge University Press:  23 September 2005

christelle adolphe  and
brandon wainwright
christelle adolphe
Affiliation:
institute for molecular bioscience, queensland bioscience precinct, building 80, services road, university of queensland, st lucia, 4072, brisbane, queensland, australia.
brandon wainwright
Affiliation:
institute for molecular bioscience, queensland bioscience precinct, building 80, services road, university of queensland, st lucia, 4072, brisbane, queensland, australia.
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Abstract

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a significant proportion of the human population suffers from some form of skin disorder, whether it be from burn injury or inherited skin anomalies. the ideal treatment for skin disorders would be to regrow skin tissue from stem cells residing in the individual patient's skin. locating these adult stem cells and elucidating the molecules involved in orchestrating the production of new skin cells are important steps in devising more-efficient methods of skin production and wound healing via the ex vivo expansion of patient keratinocytes in culture. this review focuses on the structure of the skin, the identification of skin stem cells, and the role of notch, wnt and hedgehog signalling cascades in regulating the fate of epidermal stem cells.

Keywords

epidermishedgehogwntnotchepidermal stem cellsskin regenerationskin cancer
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 7 , Issue 20 , 23 September 2005 , pp. 1 - 14
Copyright
cambridge university press 2005