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Nonviral gene delivery: techniques and implications for molecular medicine

Published online by Cambridge University Press:  13 February 2004

Alan L. Parker ,
Christopher Newman ,
Simon Briggs ,
Leonard Seymour  and
Paul J. Sheridan
Alan L. Parker
Affiliation:
CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Christopher Newman
Affiliation:
Cardiovascular Research Group, The University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Sheffield, S5 7AU, UK.
Simon Briggs
Affiliation:
School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Leonard Seymour
Affiliation:
Department of Clinical Pharmacology, Oxford University, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, UK.
Paul J. Sheridan
Affiliation:
Cardiovascular Research Group, The University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Sheffield, S5 7AU, UK.
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Abstract

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Medical research continues to illuminate the origins of many human diseases. Gene therapy has been widely proposed as a novel strategy by which this knowledge can be used to deliver new and improved therapies. Viral gene transfer is relatively efficient but there are concerns relating to the use of viral vectors in humans. Conversely, nonviral vectors appear safe but inefficient. Therefore, the development of an efficient nonviral vector remains a highly desirable goal. This review focuses on the numerous challenges preventing efficient nonviral gene transfer in vivo and discusses the many technologies that have been adopted to overcome these problems.

Keywords

Nonviral gene deliverygene therapyultrasoundnaked DNApolyplexlipoplextransgen
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 5 , Issue 22 , 3 September 2003 , pp. 1 - 15
Copyright
© Cambridge University Press 2003