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Kaposi's sarcoma: the role of HHV-8 and HIV-1 in pathogenesis

Published online by Cambridge University Press:  12 February 2004

Kimberly E. Foreman
Kimberly E. Foreman
Affiliation:
Department of Pathology, Skin Cancer Research Laboratories, Loyola University Medical CentreOncology Institute – Room 302, 2160 South First Avenue, Maywood, IL 60153-5385, USA.
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Abstract

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Kaposi's sarcoma (KS) is the most common neoplasm in acquired immune deficiency syndrome (AIDS) patients, with up to 20% of individuals infected with human immunodeficiency virus 1 (HIV-1) afflicted with this multifocal, systemic disease. For many years, scientists have striven to understand the complex pathogenesis of KS. Although experts generally agree on several key points [such as human herpesvirus 8 (HHV-8) being necessary but not sufficient for the development of KS], many questions still remain unanswered. This review summarises current theories on the molecular pathogenesis of KS, including the role of HHV-8, HIV-related proteins and growth factors in the initiation and progression of AIDS-related KS.

Keywords

HHV-8herpesvirusHIV-1AIDSKaposi’s sarcomaTatcytokinehuman immunodeficiency virusacquired immune deficiency syndrome
Type
Review Article
Information
Expert Reviews in Molecular Medicine , Volume 3 , Issue 9 , 26 March 2001 , pp. 1 - 17
Copyright
© Cambridge University Press 2001