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Study of the Interactions Between Magnesium, Ketamine and Morphine on Acute Nociception in Rats

Published online by Cambridge University Press:  23 March 2020

K. Savic Vujovic ,
A. Vujovic ,
S. Vuckovic ,
B. Medic  and
M. Prostran
K. Savic Vujovic
Affiliation:
Faculty of Medicine- University of Belgrade, Department of pharmacology- clinical pharmacology and toxicology, Belgrade, Serbia
A. Vujovic
Affiliation:
KBC Dragisa Misovic, Hospital for ENT, Belgrade, Serbia
S. Vuckovic
Affiliation:
Faculty of Medicine- University of Belgrade, Department of pharmacology- clinical pharmacology and toxicology, Belgrade, Serbia
B. Medic
Affiliation:
Faculty of Medicine- University of Belgrade, Department of pharmacology- clinical pharmacology and toxicology, Belgrade, Serbia
M. Prostran
Affiliation:
Faculty of Medicine- University of Belgrade, Department of pharmacology- clinical pharmacology and toxicology, Belgrade, Serbia

Abstract

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Objectives

Study is aimed at evaluating the effects of ketamine and magnesium sulphate on acute nociceptive pain in rats and examination whether magnesium sulfate added to ketamine or morphine-ketamine combination produces higher level of analgesia.

Methods

Analgesic activity was assessed by tail-immersion test in male Wistar rats (200–250 g).

Results

Magnesium sulfate (2.5–60 mg/kg, s.c.) and ketamine (2.5-30 mg/kg, i.p.) given alone did not produce any effect on antinociception. However, there is a synergistic interaction between ketamine (2.5, 5 and 10 mg/kg) and magnesium sulfate (5 mg/kg). Both ketamine and magnesium sulfate, as well as their combination potentiated the antinociceptive effect of morphine (2.6 mg/kg, i.p.).

Conclusion

This study revealed potentiation of ketamine and morphine-ketamine combination by magnesium sulphate in tail-immersion test in rats with higher activity when ketamine is given before magnesium sulfate. It is first time to demonstrate the synergistic interaction between magnesium sulphate and ketamine in lowering body temperature and in antinociception with statistical confirmation.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Viewing: Pain and treatment options
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S708 - S709
Copyright
Copyright © European Psychiatric Association 2017
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