There is a growing interest about comorbidity between bipolar disorders and epilepsy expressed in three perspectives: clinical, therapeutic and neuroscientist.

The prevalence of bipolar disorder among epileptic patients is about 0.1 to 5%.

At a clinical level, there are peri-ictal, inter-ictal bipolar troubles and those induced by the treatments (drugs, electric and surgical) of the epilepsy.

It seems that bipolar disorders have clinically specific characteristics (rapid cycles, less severe symptoms with each episode), where there is an association with epilepsy.

Then, therapeutic management of bipolar disorders among epileptic patients is specific.

The objective of this work is developed through a literature review, the clinical, the therapeutic and the evolutive characteristics of these disorders when found simultaneously.