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P01-24 - Quetiapine XR in Rapid Cycling Bipolar Disorder-depressive Episode - Study Case

Published online by Cambridge University Press:  17 April 2020

I. Dan  and
M. Grimberg
I. Dan
Affiliation:
Department 10 ‘Prof. Dr. Alexandru Obregia’, Bucharest, Romania
M. Grimberg
Affiliation:
Clinical Hospital ‘Prof. Dr. Alexandru Obregia’, Bucharest, Romania

Abstract

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Background

A partial solved issues in the treatment of Bipolar Disorder (BD) is depressive episode if is rapid cycling. Often, antidepressant monotherapy increases the risk of switching into mania/hypomania. Using quetiapine XR in these cases may help to avoid these disease burdens.

The aim

To estimate the clinical efficacy and acceptability, in rapid cycling depressive episode of quetiapine XR.

Methods

34 yrs. woman, Bipolar Disorder-Depressive Episode, rapid cycling (DSM-IV), scores YMRS=10 and HAMD-17=32 at baseline.

Instruments

Depression (HAMD-17), mania (YMRS), CGI-S, CGI-I, side effects and relapse (follow-up: 12 month). The patient has a history of 12 yrs. of BD with 5 depressive and 6 manic episodes. Last year depressive episodes were 3 manic and 1 depressive episodes.

Results

After 4 weeks, of treatment with quetiapine XR 300mg/day in the evening, the depressive scores improved 75%, sleep became normal, no co-medication was needed. The patient continued to receive quetiapine XR and assessments were performed monthly. The follow-up priod demonstrated no relapses (depressive or manic).

Conclusions

1. In this case of Bipolar Disorder-rapid cycling, the treatment of depressive episode quetiapine XR-300mg/day was effective and well tolerated; no switch in manic or hippomanic was noticed.

Type
Affective disorders / Unipolar depression / Bipolar disorder
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E243
Copyright
Copyright © European Psychiatric Association 2010

References

Suppes, T., et al.Effectiveness of the new extended-release formulations of quetiapine as monotherapy for the treatment of acute bipolar depression. Int J Neuropsychopharmacol 2008;11 185(Supplement S1)Google Scholar
Susan, McElroy et al, A double-blind, placebo-controlled study of quetiapine and paroxetine in adults with bipolar depression (EMBOLDEN II study acute phase, poster, ECNP Congress, September 2008, Barcelona.Google Scholar
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