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Amisulpride versus fluoxetine in dysthymia: preliminary results of a double-blind comparative study

Published online by Cambridge University Press:  16 April 2020

E Smeraldi ,
E Haefele ,
G Crespi ,
GL Casadei ,
F Biondi  and
E Vigorelli
E Smeraldi
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
E Haefele
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
G Crespi
Affiliation:
Ospedale San Raffaele, via Prinetti 29, 20127Milan
GL Casadei
Affiliation:
Medical Department, Synthélabo, Limito, Italy
F Biondi
Affiliation:
Medical Department, Synthélabo, Limito, Italy
E Vigorelli
Affiliation:
Medical Department, Synthélabo, Limito, Italy
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Summary

The efficacy and safety of low doses of amisulpride (50 mg/day) and of fluoxetine (20 mg/day) were compared respectively in 139 and 129 outpatients with dysthymia during three months in a multi-centre double-blind trial. No statistically significant difference between the two groups was found in the number of responders at study-end with the Montgomery and Asberg Depressive Rating Scale, which was the main criterion for efficacy. In addition, amisulpride was well tolerated. These preliminary results suggest that low doses of amisulpride may be effective in the treatment of dysthymic patients.

Keywords

amisulpridebenzamidetreatmentdysthymiafluoxetine
Type
Research Article
Information
European Psychiatry , Volume 11 , Issue S3 , 1996 , pp. 141s - 143s
Copyright
Copyright © Elsevier paris 1996

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References

Agnoli, ARavizza, LTrota, RStudio controllato in doppio cieco nelle sindromi distimiche (amisulpride vs amitriptilina). Suppl II XXXVII Congresso SIP Roma 6–11 Febbraio 1989Google Scholar
Boyer, PLecrubier, YPuech, A et al. Treatment of dysthymia with low doses of amisulpride vs amineptine. Clin Neuropharmacol 1992; 15(1B):2310.1097/00002826-199202001-01022CrossRefGoogle Scholar
Carnoy, PRavard, SHervé, D et al. Behavioural deficits induced by low doses of apomorphine in rats: evidence for motivational and cognitive dysfunctions which discriminate among neuroleptic drugs. Pharmacol Biochem Behav 1986; 25:503–910.1016/0091-3057(86)90131-0CrossRefGoogle Scholar
Frances, ARecurrent brief depression, dysthymia and melancholia. Intern Clin Psychopharmacol 1993; 7:197–200CrossRefGoogle ScholarPubMed
Lecrubier, YPuech, AJAubin, F et al. Comparative double-blind study of two doses of amisulpride (25 and 50 mg) and placebo in the treatment of the negative syndrome of non-psychotic subjects. In: Borenstein, PBoyer, PBraconnier, A et al. Amisulpride. Paris: Expansion Scientifique Française, 1989; 167–79Google Scholar
Lecrubier, YPharmacological intervention in dysthymia. Eur Psychiatry 1996; this issueGoogle Scholar
Martres, MPSokoloff, PDelandre, MSchwarts, JCProtai, PCostentin, JSelection of dopamine antagonists discriminating various behavioral responders and radioligand binding sites. Arch Pharmacol 1984; 325(2):102–15CrossRefGoogle Scholar
Maubrey, MCJacquot, CGonidec, J et al. Amisulpride: pharmacological and biochemical profiles. In: Borenstein, PBoyer, PBraconnier, A et al. Amisulpride. Paris: Expansion Scientifique Française, 1989; 3–23Google Scholar
Puech, AJSimon, PBoissier, JRBenzamides and classical neuroleptics. Comparison of their action using 6-apomorphine- induced effects. Eur J Pharmacol 1978; 50:291–300CrossRefGoogle Scholar
Rioux, PEtude comparative DAN 2163: DAN 2163 comprimés 50 mg/100 mg placebo dans le traitement de l'inhibition psychomotrice chez les malades de type psychasténique. Internai Report 2163 D 483, 1984 (data on file)Google Scholar
Scarzella, RScarzella, LRovera, GGAmisulpride vs sulpiride, studio clinico in doppio cieco su 68 pazienti affetti da disturbo distimico. Giornale Neuropsicofarm 1988; 2:73–8Google Scholar
Stakes, PEFluoxetine: a five-year review. Clin Ther 1993; 15:216–43Google Scholar
Ungersted, UHerrera-Marschitz, MSharp, TStaehle, LTossmann, UZettrestrom, TCaractensation pharmacologique de Dogmatil: effets pré et post synaptiques sur les récepteurs dopaminergiques. Sem Hôp Paris 1985; 61(19): 1283–1287Google Scholar
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