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Dementia and the Neurovirulence of HIV-1

Published online by Cambridge University Press:  07 November 2014

Paul Shapshak ,
Robert K. Fujimura ,
Ashok Srivastava  and
Karl Goodkin
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Abstract

Infection with human immunodeficiency virus type 1 (HIV-1 ) leads rapidly to infection of the brain and subsequent neuropsychological impairment, including subclinical impairment, minor cognitive-motor disorder, and HIV-1–associated dementia (HAD). This article reviews HAD and the factors involved in its pathogenesis; the effectiveness of antiretroviral therapy; the prevalence of HIV-1 and subtypes; and the role of chemokines and cytokines as the capstones associated with neuropathology due to inflammation.

Type
Feature Articles
Information
CNS Spectrums , Volume 5 , Issue 4: HIV and the Central Nervous System: Part One , April 2000 , pp. 31 - 42
Copyright
Copyright © Cambridge University Press 2000

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