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F-fluorodeoxyglucose-positive emission tomography/CT imaging for left ventricular assist device-associated infections in children

Published online by Cambridge University Press:  20 July 2018

Mohammed Absi*
Affiliation:
Departments of Pediatric Cardiology and Cardiothoracic Surgery, LeBonheur Children’s Medical Center, University of Tennessee Health Sciences Center, Memphis, TN, USA
Claire Bocchini
Affiliation:
Baylor College of Medicine, Houston, TX, USA
Jack F. Price
Affiliation:
Baylor College of Medicine, Houston, TX, USA
Iki Adachi
Affiliation:
Baylor College of Medicine, Houston, TX, USA
*
*Author for correspondence: M. Absi, Departments of Pediatric Cardiology and Cardiothoracic Surgery, LeBonheur Children’s Medical Center, University of Tennessee Health Sciences Center, 49 N Dunlap, Memphis, TN 38015, USA. Tel: 901-287-6380; Fax: 901-287-5970; E-mail: mabsi@uthsc.edu
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Abstract

Left ventricular assist device implantation is an important therapeutic option for children with end-stage heart failure. However, device-related complications such as infection may occur while the patient is supported. Device-associated infection can be life-threatening, and early detection is critical. F-fluorodeoxyglucose positron emission tomography and CT is a highly sensitive imaging modality for the detection of an inflammatory response and is useful to evaluate the response to antibiotic therapy. We present two case reports of a left ventricular assist device-associated infection detected by F-fluorodeoxyglucose positron emission tomography and CT in children.

Type
Images in Congenital Cardiac Disease
Copyright
© Cambridge University Press 2018 

Case report

Two children underwent left ventricular assist device implantation (HVAD; HeartWare device, Framingham, Massachusetts, United States of America) for refractory end-stage heart failure caused by dilated cardiomyopathy. Patient 1, a 5-year-old girl, had a history of a suspected culture-negative device-related infection approximately 6 months after device placement and was treated empirically with 6 weeks of vancomycin, cefepime, and gentamicin. A period of 4 weeks after completion of this therapy, the patient presented to the cardiology clinic with epigastric pain, intermittent fever for 2 weeks, elevated serum C-reactive protein concentration (22 mg/dl), and elevated white blood cell count (24×109 cells/L). Initial investigations were performed, including culture of drainage from the percutaneous exit site, three sets of blood cultures, chest radiography, echocardiography, and a CT scan of the chest, abdomen, and pelvis with contrast, but they failed to identify any source of infection. A F-fluorodeoxyglucose-positive emission tomography/CT from head to mid-thigh was then performed. Abnormal F-fluorodeoxyglucose uptake was observed around the outflow tract of the HVAD device (see Fig 1a and b). Empirical intravenous antibiotic therapy, using vancomycin and cefepime, was initiated for culture-negative device-related infection. After antibiotic initiation, the patient became afebrile and her C-reactive protein concentration normalised. She underwent an uneventful heart transplant during her 6th week of antimicrobial therapy.

Figure 1 (a) FDG PET/CT shows increased FDG uptake which extends along the connector between the LVAD “and the aortic outflow graft (yellow arrow)”. Mild FDG uptake is seen in some bilateral axillary lymph nodes. (b) FDG PET/CT shows increased FDG uptake which extends along the connector between the LVAD and outflow graft (white arrow).

Patient 2, an 8-year-old girl with dilated cardiomyopathy with refractory end-stage heart failure, was hospitalised 10 months after left ventricular assist device implantation with fever, fatigue, and poor oral intake. Laboratory revealed a mild leucocytosis (14×109 cells/L) and elevated C-reactive protein concentration (24 mg/dl). Janeway lesions (see Fig 2) and splenomegaly were noted on physical examination, and blood cultures grew methicillin-sensitive Staphylococcus aureus. Similar to the previous patient, echocardiography and CT scan with contrast failed to localise the source of infection, and a F-fluorodeoxyglucose-positive emission tomography/CT scan was then performed. Abnormal fluorodeoxyglucose uptake was observed around the outflow tract of the device (see Fig 3), consistent with infection. Her inflammatory markers normalised and her condition improved after starting treatment with nafcillin. She completed a 6-week course of nafcillin and continued on chronic suppressive therapy with cephalexin until she successfully underwent cardiac transplantation. The tissue cultures taken at the time of explant for both cases were negative.

Figure 2 Janeway lesions.

Figure 3 FDG PET/CT shows focal intense hypermetabolic activity surrounding the LVAD outflow cannula “in the retrosternal space at the level of the inferior sternum (white arrow)”. There is mild adjacent reactive lymphadenopathy.

Left ventricular assist devices are important therapeutic options for children with end-stage heart failure. Infections are well-known complications of ventricular assist devices and increase the risk of morbidity and mortality associated with device placement. Early detection and accurate diagnosis of infection is critical for prompt initiation of appropriate management in patients with ventricular assist devices; early and appropriate management provides the best opportunity to improve outcomes in these patients.

F-fluorodeoxyglucose-positive emission tomography/CT is highly sensitive for the detection of an inflammatory response. Some adult centres have reported their experiences using positive emission tomography/CT to diagnose infections in ventricular assist device patients.Reference Kim, Feller, Chen and Dilsizian 1 Reference Akin, Muslem and Constaninescu 3 In a recent meta-analysis of the use of F-fluorodeoxyglucose-positive emission tomography/CT for detecting infections associated with implantable cardiac devices, the pooled sensitivity of F-fluorodeoxyglucose-positive emission tomography-CT was 87% and the pooled specificity was 94%.Reference Juneau, Golfam and Hazra 4 The area under the curve of the receiver operating characteristics analysis showed good accuracy at 0.952. Among ventricular assist device patients, a study of 31 adults showed a sensitivity of 100% and a specificity of 80% for identifying infections.Reference Dell’Aquilla, Mastrobuoni and Alles 5

Other imaging modalities have been used to diagnose infection in ventricular assist device patients. A transthoracic or transesophageal echocardiogram can identify vegetations within the heart, suggestive of endocarditis, but has limited utility beyond that. Abdominal ultrasound and standard CT scan of the chest and abdomen can identify nonspecific fluid collections around the driveline and pump pocket. The use of F-fluorodeoxyglucose-positive emission tomography/CT, however, may provide a more precise location of an inflammatory process and may allow for earlier and more accurate detection.Reference Trachtenberg, Cordero-Reyes, Elias and Loebe 6 One potential limitation of this imaging modality is that patients should receive a low-carbohydrate diet for 24 hours before the study to optimise images by reducing physiological myocardial uptake.Reference Akin, Muslem and Constaninescu 3 Despite this limitation, positive emission tomography/CT appears to be a helpful imaging modality for adult and now paediatric ventricular assist device patients with suspected infectious complications.

Acknowledgements

The authors would like to acknowledge the contribution of Dr Antonio Cabrera to this work.

Financial Support

This research received no specific grant from any funding agency or from commercial or not-for-profit sectors.

Conflicts of Interest

None.

Ethical Standards

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national guides and has been approved by the institutional committee of involved institutions.

References

1. Kim, J, Feller, ED, Chen, W, Dilsizian, V. FDG PET/CT imaging for LVAD associated infections. JACC Cardiovasc Imaging 2014; 7: 839842.Google Scholar
2. Tlili, G, Picard, F, Pinaquy, J, Domingues-Dos-Santos, P, Bordenave, L. The usefulness of FDG Pet/CT in suspicion of LVAD infection. J Nucl Cardiol 2014; 21: 845848.Google Scholar
3. Akin, S, Muslem, R, Constaninescu, AA, et al. 18F-FDG PET/CT in the diagnosis and management of continuous flow left ventricular assist device infections: a case series and review of the literature. ASAIO J, 2017 February 21 [Epub ahead of print].Google Scholar
4. Juneau, D, Golfam, M, Hazra, S, et al. Positron emission tomography and single-photon emission computed tomography imaging in the diagnosis of cardiac implantable electronic device infection: a systematic review and meta-analysis. Circ Cardiovasc Imaging 2017; 10: 111.Google Scholar
5. Dell’Aquilla, Am, Mastrobuoni, S, Alles, S, et al. Contributory role of fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography in the diagnosis and clinical management of infections in patients supported with a continuous-flow left ventricular assist device. Ann Thorac Surg 2016; 101: 8794.Google Scholar
6. Trachtenberg, BH, Cordero-Reyes, A, Elias, B, Loebe, M. A review of infections in patients with left ventricular assist devices: prevention, diagnosis and management. Methodist Debakey Cardiovasc J 2015; 11: 2832.Google Scholar
Figure 0

Figure 1 (a) FDG PET/CT shows increased FDG uptake which extends along the connector between the LVAD “and the aortic outflow graft (yellow arrow)”. Mild FDG uptake is seen in some bilateral axillary lymph nodes. (b) FDG PET/CT shows increased FDG uptake which extends along the connector between the LVAD and outflow graft (white arrow).

Figure 1

Figure 2 Janeway lesions.

Figure 2

Figure 3 FDG PET/CT shows focal intense hypermetabolic activity surrounding the LVAD outflow cannula “in the retrosternal space at the level of the inferior sternum (white arrow)”. There is mild adjacent reactive lymphadenopathy.