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End-systolic wall stress is a major determinant of postoperative left ventricular dysfunction in patients with congenital mitral regurgitation

Published online by Cambridge University Press:  15 August 2006

Tomoaki Murakami ,
Makoto Nakazawa ,
Toshio Nakanishi  and
Kazuo Momma
Tomoaki Murakami
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan
Makoto Nakazawa
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan
Toshio Nakanishi
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan
Kazuo Momma
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan
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Abstract

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To clarify the contribution of afterload to left ventricular performance after repair of mitral regurgitation, we evaluated echocardiographically 8 children who had undergone surgical repair for isolated congenital mitral regurgitation. We examined the relationship between left ventricular systolic function and preload, afterload, and contractility. The left ventricular systolic function was strongly correlated with the afterload after the surgical repair. In the postoperative state, reducing afterload by vasodilators could be a useful means of treating cardiac failure, in addition to using catecholamines to increase the contractility.

Keywords

Afterloadafterload mismatchmitral regurgitation
Type
Original Article
Information
Cardiology in the Young , Volume 12 , Issue 3 , May 2002 , pp. 236 - 239
Copyright
2002 Cambridge University Press