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Treatment of Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

W.R. Wayne Martin  and
Marguerite Wieler
W.R. Wayne Martin
Affiliation:
Division of Neurology, University of Alberta, Edmonton, AB Canada
Marguerite Wieler
Affiliation:
Division of Neurology, University of Alberta, Edmonton, AB Canada
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Abstract

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Parkinson's disease is a progressive neurodegenerative disorder that demands a holistic approach to treatment. Both pharmacologic and nonpharmacologic interventions play an important role in the comprehensive management of this disorder. While levodopa remains the single most effective medication for symptomatic treatment, dopamine agonists are playing an increasingly important role. Motor complications of dopaminergic therapy are a significant issue, particularly in patients with more advanced disease who have been on levodopa for several years. All therapeutic interventions must be tailored to the individual and modified as the disease progresses, with the goal of minimizing significant functional disability as much as possible.

Résumé

RÉSUMÉ

La maladie de Parkinson est une maladie neurodégénératrice progressive dont le traitement nécessite une approche holistique. Les interventions tant pharmacologiques que non pharmacologiques jouent un rôle important dans la prise en charge de cette maladie. Bien que la lévodopa demeure la pierre angulaire du traitement symptomatique, les agonistes de la dopamine jouent un rôle de plus en plus important. Les complications motrices de la thérapie dopaminergique constituent un problème important, particulièrement chez les patients en phase avancée de la maladie qui prennent de la lévodopa depuis plusieurs années. Les interventions thérapeutiques doivent être adaptées à chaque patient et modifiées à mesure que la maladie progresse, dans le but de minimiser autant que possible l’invalidité fonctionnelle.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 30 , supplement S1: A Peer-Reviewed Supplement to the Canadian Journal of Neurological Sciences , February 2003 , pp. S27 - S33
Copyright
Copyright © The Canadian Journal of Neurological 2003

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