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Platelet taurine content in Friedreich's disease

Published online by Cambridge University Press:  18 September 2015

F. Rodrigue ,
F. Bélanger ,
N.M. van Gelder  and
A. Barbeau
F. Rodrigue
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
F. Bélanger
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
N.M. van Gelder
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
A. Barbeau*
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Abstract

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We have studied the concentrations of taurine and of 6 other amino acids in platelets from 12 patients with Friedreich's disease and 12 age sex-matched normal control subjects. No significant differences could be demonstrated between the two groups. The glycine/serine ratio was lower in all the patients but this change did not reach statistical significance. From these and other data, we conclude that the taurine retention deficit observed previously in Friedreich's disease cannot be the primary causal defect.

Type
C—Biochemistry
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 607 - 609
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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