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Pharmacological and Biochemical Evidence for the Existence of Two Categories of Dopamine Receptor

Published online by Cambridge University Press:  18 September 2015

J.W. Kebabian ,
M. Beaulieu  and
Y. Itoh
M. Beaulieu
Affiliation:
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke NIH, Bethesda, MD
Y. Itoh
Affiliation:
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke NIH, Bethesda, MD
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Abstract

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Evidence supporting the validity of the ‘two dopamine receptor’ hypothesis is presented. The availability of the ‘first generation’ of selective agonists and antagonists of the D-1 and the D-2 dopamine receptors provides pharmacological support for the hypothesis. The demonstration that stimulation of the D-2 receptor either inhibits or has no effect upon adenylate cyclase activity while stimulation of the D-1 receptor enhances cAMP formation provides biochemical support for the hypothesis. Finally, binding assays demonstrating two affinity states for the D-1 and the D-2 receptors are briefly discussed.

Type
1. Neurotransmitters and the Pharmacology of the Basal Ganglia
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 114 - 117
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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