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Cardiac malic enzyme in Friedreich's disease

Published online by Cambridge University Press:  18 September 2015

A. Barbeau ,
M. Charbonneau ,
T. Cloutier  and
B. Lemieux
A. Barbeau*
Affiliation:
Clinical Research Institute of Montreal
M. Charbonneau
Affiliation:
Clinical Research Institute of Montreal
T. Cloutier
Affiliation:
Clinical Research Institute of Montreal
B. Lemieux
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W IR7
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Abstract

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We measured the activity of cytosolic and of mitochondrial malic enzyme in the hearts from 4 patients with Friedreich's disease and from two non-ataxic control subjects. There was a wide variability in the results and the slight overall decreases in both enzyme activities were not considered to be statistically significant. From these and other results, we conclude that deficient mitochondrial malic enzyme activity is not a constant or primary feature of Friedreich's disease.

Type
C—Biochemistry
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 643 - 645
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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