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Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal trophic factors*

Published online by Cambridge University Press:  09 March 2007

Takashi Sakata
Takashi Sakata
Affiliation:
Yakult Central Institute for Microbiological Research, Physiology Group, Kunitachi 186, Japan
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Abstract

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1. Effects of short-chain fatty acids (SCFA) on epithelial proliferation of the intestine were studied in ileally fistulated rats fed on an elemental diet.

2. The stimulatory effect of daily doses of acetic, propionic and n-butyric acids (100,20 and 60 mM respectively; pH 6.1) per fistula (3 ml, twice daily) on crypt cell production rate (CCPR) appeared within 2 d and lasted for at least 5 d.

3. The daily doses of SCFA for 14 d increased daily CCPR three to four fold. This effect was independent of the presence of gut bacteria.

4. Effects of SCFA were dose-dependent and varied among acids (butyrate > propionate > acetate). The effect was independent of low lumen pH.

5. In contrast, SCFA inhibited epithelial proliferation of isolated rat caecal tissue in vitro.

6. These results suggest that SCFA are physiological lumen trophic factors mediated by a systemic mechanism in vivo.

7. It is concluded that SCFA are involved in the trophic effects of gut microbes, ingestion of fermentable fibre, and lumen contents.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 95 - 103
Copyright
Copyright © The Nutrition Society 1987

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