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Nutrition and cancer: the current epidemiological evidence

Published online by Cambridge University Press:  08 March 2007

Carlos A. Gonzalez
Carlos A. Gonzalez*
Affiliation:
Department of Epidemiology and Cancer Registry, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology, Gran Via s/n, Hospitalet de Llobregat-Barcelona, Spain
*
*Corresponding author: Dr Carlos A. Gonzalez, fax +34 932 697401, email cagonzalez@ico.scs.es
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Abstract

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We have examined the current scientific evidence on the relationship between nutrition and the most frequent tumours in the Spanish population: lung, colorectal, prostate, breast and stomach. Consumption of fruit is negatively associated with cancer of the lung and stomach, possibly with colorectal cancer, but probably not with prostate cancer and breast cancer. Consumption of vegetables probably reduces the risk of colorectal and stomach cancer, but probably is not associated with cancer of the lung, prostate and breast. Consumption of red and processed meat is positively associated with colorectal cancer and probably with stomach cancer. Animal fat is possibly associated with colorectal cancer and probably with prostate and breast cancer. High alcohol intake increases the risk of colorectal and breast cancer, while dairy products and calcium seem to decrease the risk of colorectal cancer. Obesity is a recognised risk factor of colorectal cancer and breast cancer in postmenopausal women, while foods with a high glycaemic index and glycaemic load possibly increase the risk of colorectal and prostate cancer. The relevance of nutrition on the cancer process is evident. Nevertheless important issues remain to be solved and further studies are needed. This accumulative knowledge should be used by public health authorities to develop recommendations and activities to reduce overweight and obesity and to promote healthy dietary habits.

Keywords

Nutrition and cancerEpidemiological evidence
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue S1 , August 2006 , pp. S42 - S45
Copyright
Copyright © The Nutrition Society 2006

References

Bjelakovic, G, Nikolova, D, Simonetti, RG & Gluud, C (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364, 1219–1228.CrossRefGoogle ScholarPubMed
Boyd, NF, Stone, J, Vogt, KN, Connelly, BS, Martin, LJ & Minkin, S (2003) Dietary fat and breast cancer risk revisited: a meta-analysis of the published literature. Br J Cancer 89, 1672–1685.CrossRefGoogle ScholarPubMed
Cho, E, Smith-Warner, SA, Ritz, J et al. (2004) Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Ann Int Med 140, 603–613.CrossRefGoogle ScholarPubMed
Correa, P, Fontham, ET, Bravo, JC et al. (2000) Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy. J Natl Cancer Inst 92, 1881–1888.CrossRefGoogle ScholarPubMed
Hamajima, N, Hirose, K, Tajima, K et al. (2002) Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies, including 58, 515 women with breast cancer and 95 067 women without the disease. Br J Cancer 87, 1234–1245.Google Scholar
International Agency for Research on Cancer (2002) Weight Control and Physical Activity. IARC Handbooks of Cancer Prevention no. 6. Lyon: IARC Press.Google Scholar
Kaaks, R & Lukanova, A (2001) Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 60, 91–106.CrossRefGoogle ScholarPubMed
Key, TJ, Allen, N, Appleby, P et al. (2004) Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130, 544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 109, 119–124.CrossRefGoogle Scholar
Kolonel, LN (2001) Fat, meat, and prostate cancer. Epidemiol Rev 23, 72–81.CrossRefGoogle ScholarPubMed
Mannisto, S, Smith-Warner, SA, Spiegelman, D et al. (2004) Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiol Biomarkers Prev 13, 40–48.CrossRefGoogle Scholar
Miller, AB, Altenburg, HP, Bueno-de-Mesquita, B et al. (2004) Fruits and vegetables and lung cancer: findings from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 108, 269–276.CrossRefGoogle ScholarPubMed
Norat, T, Lukanova, A, Ferrari, P & Riboli, E (2002) Meat consumption and colorectal cancer risk: dose–response meta-analysis of epidemiological studies. Int J Cancer 98, 241–256.CrossRefGoogle ScholarPubMed
Riboli, E & Norat, T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78 Suppl. 3, 559S–569S.CrossRefGoogle ScholarPubMed
Sandhu, MS, White, IR & McPherson, K (2001) Systematic review of the prospective cohort studies on meat consumption and colorectal cancer risk: a meta-analytical approach. Cancer Epidemiol Biomarkers Prev 10, 439–446.Google Scholar
Smith-Warner, SA, Ritz, J, Hunter, DJ et al. (2002) Dietary fat and risk of lung cancer in a pooled analysis of prospective studies. Cancer Epidemiol Biomarkers Prev 11, 987–992.Google Scholar
Smith-Warner, SA, Spiegelman, D, Yaun, SS et al. (2001) Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. JAMA 285, 769–776.CrossRefGoogle ScholarPubMed
Smith-Warner, SA, Spiegelman, D, Yaun, SS et al. (2003) Fruits, vegetables and lung cancer: a pooled analysis of cohort studies. Int J Cancer 107, 1001–1011.CrossRefGoogle ScholarPubMed
van Gils, CH, Peeters, PHM, Bueno-de-Mesquita, B et al. (2005) Consumption of vegetables and fruits and risk of breast cancer. JAMA 293, 183–193.CrossRefGoogle ScholarPubMed
Weingarten, MA, Zalmanovici, A & Yaphe, J (2004) Dietary calcium supplementation for preventing colorectal cancer and adenomatous polyps. Cochrane Database Syst Rev 1 CD003548Google Scholar
World Cancer Research Fund/American Institute for Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: WCRF/AICRGoogle Scholar