Effects of dl-2-hydroxy-4-methylthiobutyrate on the first-pass intestinal metabolism of dietary methionine and its extra-intestinal availability

Zhengfeng Fang; Feiruo Huang; Jie Luo; Hongkui Wei; Libao Ma; Siwen Jiang; Jian Peng

doi:10.1017/S0007114509992169

Fang, Zhengfeng Yao, Kang Zhang, Xiaoling Zhao, Shengjun Sun, Zhihong Tian, Gang Yu, Bing Lin, Yan Zhu, Biquan Jia, Gang Zhang, Keying Chen, Daiwen and Wu, De 2010. Nutrition and health relevant regulation of intestinal sulfur amino acid metabolism. Amino Acids, Vol. 39, Issue. 3, p. 633.

Fang, Zhengfeng Luo, Hefeng Wei, Hongkui Huang, Feiruo Qi, Zhili Jiang, Siwen and Peng, Jian 2010. Methionine Metabolism in Piglets Fed dl-Methionine or Its Hydroxy Analogue Was Affected by Distribution of Enzymes Oxidizing These Sources to Keto-Methionine. Journal of Agricultural and Food Chemistry, Vol. 58, Issue. 3, p. 2008.

Martín-Venegas, Raquel Brufau, M.Teresa Guerrero-Zamora, Ana Maria Mercier, Yves Geraert, Pierre-André and Ferrer, Ruth 2013. The methionine precursor dl-2-hydroxy-(4-methylthio)butanoic acid protects intestinal epithelial barrier function. Food Chemistry, Vol. 141, Issue. 3, p. 1702.

Li, Hao Wan, Haifeng Mercier, Yves Zhang, Xiaoling Wu, Caimei Wu, Xiuqun Tang, Li Che, Lianqiang Lin, Yan Xu, Shengyu Tian, Gang Wu, De and Fang, Zhengfeng 2014. Changes in plasma amino acid profiles, growth performance and intestinal antioxidant capacity of piglets following increased consumption of methionine as its hydroxy analogue. British Journal of Nutrition, Vol. 112, Issue. 6, p. 855.

Zhang, Xiaoling Li, Hao Liu, Guangmang Wan, Haifeng Mercier, Yves Wu, Caimei Wu, Xiuqun Che, Lianqiang Lin, Yan Xu, Shengyu Tian, Gang Chen, Daiwen Wu, De and Fang, Zhengfeng 2015. Differences in plasma metabolomics between sows feddl-methionine and its hydroxy analogue reveal a strong association of milk composition and neonatal growth with maternal methionine nutrition. British Journal of Nutrition, Vol. 113, Issue. 4, p. 585.

Mastrototaro, Lucia Sponder, Gerhard Saremi, Behnam and Aschenbach, Jörg R. 2016. Gastrointestinal methionine shuttle: Priority handling of precious goods. IUBMB Life, Vol. 68, Issue. 12, p. 924.

Moran, Edwin T. 2016. Gastric digestion of protein through pancreozyme action optimizes intestinal forms for absorption, mucin formation and villus integrity. Animal Feed Science and Technology, Vol. 221, Issue. , p. 284.

Wan, HF Zhu, JT Shen, Y Xiang, X Yin, HJ Fang, ZF Che, LQ Lin, Y Xu, SY Feng, B and Wu, D 2016. Effects of Dietary Supplementation of β‐hydroxy‐β‐methylbutyrate on Sow Performance and mRNA Expression of Myogenic Markers in Skeletal Muscle of Neonatal Piglets. Reproduction in Domestic Animals, Vol. 51, Issue. 1, p. 135.

Pan, Fei-Yu Wu, Pei Feng, Lin Jiang, Wei-Dan Kuang, Sheng-Yao Tang, Ling Tang, Wu-Neng Zhang, Yong-An Zhou, Xiao-Qiu and Liu, Yang 2017. Methionine hydroxy analogue improves intestinal immunological and physical barrier function in young grass carp ( Ctenopharyngodon idella ). Fish & Shellfish Immunology, Vol. 64, Issue. , p. 122.

Zhang, Yalin Wang, Peng Lin, Sen Mercier, Yves Yin, Huajun Song, Yumo Zhang, Xiaoling Che, Lianqiang Lin, Yan Xu, Shengyu Feng, Bin De Wu and Fang, Zhengfeng 2018. mTORC1 signaling-associated protein synthesis in porcine mammary glands was regulated by the local available methionine depending on methionine sources. Amino Acids, Vol. 50, Issue. 1, p. 105.

Zuo, Fangrui Gu, Qiongyao Li, Shengqing Wei, Hongkui and Peng, Jian 2019. Effects of Different Methionine Sources on Methionine Metabolism in the IPEC-J2 Cells. BioMed Research International, Vol. 2019, Issue. , p. 1.

Wei, Hongkui Zhao, Xichen Xia, Mao Tan, Chengquan Gao, Jun Htoo, John K. Xu, Chuanhui and Peng, Jian 2019. Different dietary methionine to lysine ratios in the lactation diet: effects on the performance of sows and their offspring and methionine metabolism in lactating sows. Journal of Animal Science and Biotechnology, Vol. 10, Issue. 1,

Rasch, Ilka Görs, Solvig Tuchscherer, Armin Htoo, John K Kuhla, Björn and Metges, Cornelia C 2019. Substitution of Dietary Sulfur Amino Acids by DL-2-hydroxy-4-Methylthiobutyric Acid Increases Remethylation and Decreases Transsulfuration in Weaned Piglets. The Journal of Nutrition, Vol. 149, Issue. 3, p. 432.

Wang, Youli Yin, Xiaonan Yin, Dafei Lei, Zhao Mahmood, Tahir and Yuan, Jianmin 2019. Antioxidant response and bioavailability of methionine hydroxy analog relative to DL-methionine in broiler chickens. Animal Nutrition, Vol. 5, Issue. 3, p. 241.

Rasch, Ilka Görs, Solvig Tuchscherer, Armin Viergutz, Torsten Metges, Cornelia C and Kuhla, Björn 2020. Substitution of Dietary Sulfur Amino Acids by ᴅʟ-2-Hydroxy-4-Methylthiobutyric Acid Reduces Fractional Glutathione Synthesis in Weaned Piglets. The Journal of Nutrition, Vol. 150, Issue. 4, p. 722.

Romanet, Stella Aschenbach, Jörg R. Pieper, Robert Zentek, Jürgen Htoo, John K. Whelan, Rose A. and Mastrototaro, Lucia 2021. Expression of proposed methionine transporters along the gastrointestinal tract of pigs and their regulation by dietary methionine sources. Genes & Nutrition, Vol. 16, Issue. 1,

Cao, Yangchun Yao, Junhu Sun, Xiaoting Liu, Shimin and Martin, Graeme B. 2021. Amino Acids in Nutrition and Health. Vol. 1285, Issue. , p. 63.

Zhang, Sai Manjarin, Rodrigo and Trottier, Nathalie L. 2022. Sustainable Swine Nutrition. p. 115.

Moran, Edwin T. and Bedford, Michael R. 2023. Endogenous mucin conveyed to the mucosa with microbes can assure lumen fermentation and large intestinal security–swine versus fowl. Animal Nutrition, Vol. 14, Issue. , p. 403.

Jiang, Qianming Sherlock, Danielle N. Guyader, Jessie and Loor, Juan J. 2023. Abundance of Amino Acid Transporters and mTOR Pathway Components in the Gastrointestinal Tract of Lactating Holstein Cows. Animals, Vol. 13, Issue. 7, p. 1189.

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