Hostname: page-component-745bb68f8f-kw2vx Total loading time: 0 Render date: 2025-02-06T23:14:16.527Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of capsaicin-sensitive afferent nerves in initiation and maintenance of pathological pain

Published online by Cambridge University Press:  01 September 1997

Gábor Jancsó ,
Mária Dux  and
Péter Sántha
Gábor Jancsó
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, Hungaryjancso@phys.szote.u-szeged.hu
Mária Dux
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, Hungaryjancso@phys.szote.u-szeged.hu
Péter Sántha
Affiliation:
Department of Physiology, Albert Szent-Györgyi Medical University, Dóm tér 10, H-6720 Szeged, Hungaryjancso@phys.szote.u-szeged.hu
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

This commentary provides experimental data in support of the critical role of capsaicin-sensitive primary afferent fibers in the initiation and maintenance of pathological pain. The demonstration of capsaicin-induced, centrally-evoked cutaneous hyperalgesia, and of neuroplastic changes elicited by the degeneration of C-fiber primary afferent terminals following peripheral nerve damage, indicates a significant contribution of capsaicin-sensitive sensory ganglion neurons in the development of pathological pain conditions. [coderre & katz]

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 454 - 455
Copyright
© 1997 Cambridge University Press