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Novel peripheral mechanisms of opioid analgesia

Published online by Cambridge University Press:  01 September 1997

Christoph Stein  and
Michael Schäfer
Christoph Stein
Affiliation:
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287-8711 cstein@gwgate1.jhmi.jhu.edu
Michael Schäfer
Affiliation:
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, MD 21287-8711 cstein@gwgate1.jhmi.jhu.edu
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Abstract

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dickenson briefly mentions that peripheral opioid receptors somehow become active following inflammation and that the appearance of endogenous opioid peptides at the injury site may be related to immune cell proliferation. Recent findings elucidate the underlying mechanisms in more detail and provide an incentive for the development of a novel generation of analgesics devoid of typical central opioid side effects.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 3 , September 1997 , pp. 465 - 466
Copyright
© 1997 Cambridge University Press