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Natural selection and schizophrenia

Published online by Cambridge University Press:  15 June 2005

Roger J. Sullivan  and
John S. Allen
Roger J. Sullivan*
Affiliation:
Department of Anthropology, California State University, Sacramento, Sacramento, CA95819-6106www.csus.edu/indiv/s/sullivanr
John S. Allen*
Affiliation:
Department of Neurology, The University of Iowa Hospitals and Clinics, Iowa City, IA52242
*
sullivar@csus.edu
jsallen38@aol.com
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Abstract:

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Evolutionary theories of schizophrenia must account for the maintenance of putative alleles in past and present populations despite reduced fitness among the affected. Such models must also account for extant intersex and population-level variability in the expression of schizophrenia. We argue that genetic balanced-polymorphism hypotheses remain the most robust in terms of modeling and testing these processes in populations.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 27 , Issue 6 , December 2004 , pp. 865 - 866
Copyright
Copyright © Cambridge University Press 2004