Dopamine and serotonin: Integrating current affective engagement with longer-term goals

Leonard D. Katz

doi:10.1017/S0140525X99312048

Abstract

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Interpreting VTA dopamine activity as a facilitator of affective engagement fits Depue & Collins's agency dimension of extraverted personality and also Watson's and Tellegen's (1985) engagement dimension of state mood. Serotonin, by turning down the gain on dopaminergic affective engagement, would permit already prepotent responses or habits to prevail against the behavior-switching incentive-simulation-driven temptations of the moment facilitated by fickle VTA DA. Intelligent switching between openly responsive affective engagement and constraint by long-term plans, goals, or values presumably involves environment-sensitive balancing of these neuromodulators, such as socially dominant primates may show.

Crossref Citations

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Allen, Nicholas B. and Badcock, Paul B. T. 2003. The Social Risk Hypothesis of Depressed Mood: Evolutionary, Psychosocial, and Neurobiological Perspectives.. Psychological Bulletin, Vol. 129, Issue. 6, p. 887.

Huppert, F. A. Baylis, N. Keverne, B. Ryff, Carol D. Singer, Burton H. and Dienberg Love, Gayle 2004. Positive health: connecting well–being with biology. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, Vol. 359, Issue. 1449, p. 1383.

Allen, Nicholas B. and Badcock, Paul B.T. 2006. Darwinian models of depression: A review of evolutionary accounts of mood and mood disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 30, Issue. 5, p. 815.

van den Bos, Ruud and de Ridder, Denise 2006. Evolved to satisfy our immediate needs: Self-control and the rewarding properties of food. Appetite, Vol. 47, Issue. 1, p. 24.

van den Bos, Ruud Houx, Bart B. and Spruijt, Berry M. 2006. The effect of reward magnitude differences on choosing disadvantageous decks in the Iowa Gambling Task. Biological Psychology, Vol. 71, Issue. 2, p. 155.

Davey, Christopher G. Yücel, Murat and Allen, Nicholas B. 2008. The emergence of depression in adolescence: Development of the prefrontal cortex and the representation of reward. Neuroscience & Biobehavioral Reviews, Vol. 32, Issue. 1, p. 1.

Weir, John M. Zakama, Arthurine and Rao, Uma 2012. Developmental Risk I: Depression and the Developing Brain. Child and Adolescent Psychiatric Clinics of North America, Vol. 21, Issue. 2, p. 237.

Shoval, Gal Bar-Shira, Ossnat Zalsman, Gil John Mann, J. and Chechik, Gal 2014. Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence. European Neuropsychopharmacology, Vol. 24, Issue. 7, p. 1123.

Cousins, Lesley and Goodyer, Ian M 2015. Antidepressants and the adolescent brain. Journal of Psychopharmacology, Vol. 29, Issue. 5, p. 545.

Moeller, Julia Eccles, Jacquelynne S. Salmela-Aro, Katariina Dietrich, Julia Schneider, Barbara and Grassinger, Robert 2015. International Encyclopedia of the Social & Behavioral Sciences. p. 570.

Rao, Uma and Lei, Tiffany 2019. Clinical Handbook for the Diagnosis and Treatment of Pediatric Mood Disorders. p. 105.

Wijngaards, Indy King, Owen C. Burger, Martijn J. and van Exel, Job 2022. Worker Well-Being: What it Is, and how it Should Be Measured. Applied Research in Quality of Life, Vol. 17, Issue. 2, p. 795.

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Dopamine and serotonin: Integrating current affective engagement with longer-term goals

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