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Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia

Published online by Cambridge University Press:  15 June 2005

Ralph E. Hoffman ,
Daniel H. Mathalon ,
Judith M. Ford  and
John H. Krystal
Ralph E. Hoffman*
Affiliation:
Department of Psychiatry, Yale University School of Medicine, Yale–New Haven Psychiatric Hospital, New Haven, CT06519
Daniel H. Mathalon*
Affiliation:
Department of Psychiatry, Yale University School of Medicine, Psychiatry Service 116A, VA Connecticut Healthcare System, West Haven, CT06516
Judith M. Ford*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA94305-5550
John H. Krystal*
Affiliation:
Department of Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, New Haven, CT06519
*
ralph.hoffman@yale.edu
daniel.mathalon@yale.edu
jford@stanford.edu
john.krystal@yale.edu
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Abstract:

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Transcranial magnetic stimulation, EEG, and behavioral studies by our group implicate spurious activation of speech perception neurocircuitry in the genesis of auditory hallucinations in schizophrenia. The neurobiological basis of these abnormalities remains uncertain, however. We review our ongoing studies, which suggest that altered cortical coupling underlies speech processing in schizophrenia and is expressed via disrupted gamma resonances and impaired corollary discharge function of self-generated verbal thought.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 27 , Issue 6 , December 2004 , pp. 797 - 798
Copyright
Copyright © Cambridge University Press 2004