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Beyond attention: The role of amygdala NMDA receptors in fear conditioning

Published online by Cambridge University Press:  01 December 1997

Jonathan C. Gewirtz  and
Michael Davis
Jonathan C. Gewirtz
Affiliation:
Departments of Psychiatry and Psychology, Yale University, Ribicoff Research Facilities of the Connecticut Mental Health Center, New Haven, CT 06508 jonathan.gewirtz@yale.edumdavis@biomed.med.yale.edu
Michael Davis
Affiliation:
Departments of Psychiatry and Psychology, Yale University, Ribicoff Research Facilities of the Connecticut Mental Health Center, New Haven, CT 06508 jonathan.gewirtz@yale.edumdavis@biomed.med.yale.edu
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Abstract

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Several types of amygdala-dependent learning can be blocked by local infusion of NMDA antagonists into the amygdala. This blockade shows anatomical, pharmacological, temporal, and behavioral specificity, providing a pattern of data more consistent with a role for NMDA receptors in learning than in arousal or attention, and supporting the contention that an “LTP-like” process is a neural substrate for memory formation.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 20 , Issue 4 , December 1997 , pp. 618 - 619
Copyright
© 1997 Cambridge University Press