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Metabolic Research in Monozygotic Twins with Diabetes Mellitus: Progress Report*

Published online by Cambridge University Press:  27 January 2025

T. Goecke ,
W. Grote  and
D. Grueneklee
T. Goecke*
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
W. Grote
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
D. Grueneklee
Affiliation:
Department of Human Genetics and Anthropology and Diabetes Research Institute, University of Düsseldorf, German Federal Republic
*
Institut für Humangenetik und Anthropologie, Ulenbergstrasse 127/129, Düsseldorf, German Federal Republic

Abstract

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An intravenous and oral glucose tolerance test and an intravenous tolbutamide test have been performed in 11 MZ twin pairs, discordant for diabetes mellitus. Blood sugar, immunoreactive insulin, and free fatty acids were determined. The research aimed at finding out whether prediabetic subjects may show any characteristic parameter which could be suggestive of the hereditary disposition. Three MZ twins of juvenile diabetics showed a normal blood glucose, immunoreactive insulin, and free fatty acids during the glucose and tolbutamide loads within a maximum of 10 years observation.

Type
7. Twin Studies in Medical and Clinical Genetics
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 25 , January 1976 , pp. 281 - 288
Copyright
Copyright © The International Society for Twin Studies 1976

Footnotes

*

The investigations have been supported by the Deutsche Forschungs-Gemeinschaft.

References

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