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Experimental Inhibition of the Virus-Induced Rauscher Leukemia of the Mouse

Published online by Cambridge University Press:  01 August 2014

H. J. Seidel
H. J. Seidel*
Affiliation:
Institut für Experimentelle Pathologie der Farbenfabriken Bayer A. G., Wuppertal-Elberfeld

Summary

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Chemotherapy of murine Rauscher virus-induced leukemia using Trenimon, 6-Mercaptopurine, 5-Fluorouracil and Melphalan is described. Therapy is based on nucleated cell counts in peripheral blood and body weight of the animals. Remarkable remissions of the number of nucleated cells — not occurring in untreated animals — are induced by Trenimon and 6-Mercaptopurine. Prolongation of survival times exceeds 100% in the groups treated with Trenimon, 6-Mercaptopurine, and 5-Fluorouracil.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 17 , Issue 1 , January 1968 , pp. 9 - 17
Copyright
Copyright © The International Society for Twin Studies 1967

References

Boiron, M. et al. (1965). Pathogenesis of Rauscher leukemia. J. Nat. Cancer Inst., 35: 865–884.Google Scholar
Chirigos, M. A. et al. (1963). Studies with the murine leukemogenic Rauscher virus. I. Chemotherapy studies with in vivo and in vitro assay systems. Cancer Res., 23: 762–769.Google Scholar
Chirigos, M. A. (1963). II. Chemotherapy of virus-induced lymphoid leukemia. Cancer Res., 23: 1646–50.Google Scholar
Rauscher, F. J. (1962). A virus-induced disease of mice characterized by erythropoiesis and lymphoid leukemia. J. Nat. Cancer Inst., 29: 515–532.Google Scholar
Siegel, B. V. et al. (1964). Mouse erythroleukemia of viral aetiology. Nature, 201: 1042–1043.Google Scholar