Susceptibility to Infectious Diseases: The Importance of Host Genetics

doi:10.1017/CBO9780511546235

Susceptibility to Infectious Diseases

The Importance of Host Genetics

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Kaslow, Richard A Shrestha, Sadeep and Tang, Jianming ‘James’ 2008. Encyclopedia of Life Sciences.

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Zhang, Y.X. Xue, Y. Liu, J.Y. Zhao, M.Y. Li, F.J. Zhou, J.M. Wang, H.J. and Li, J.C. 2011. Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population. Genetics and Molecular Research, Vol. 10, Issue. 1, p. 7.

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Edited by Richard Bellamy, Kintampo Health Research Centre, Ghana

Publisher:: Cambridge University Press
Online publication date:: August 2009
Print publication year:: 2003
Online ISBN:: 9780511546235
DOI:: https://doi.org/10.1017/CBO9780511546235

Subjects:: Life Sciences, Pathology and Laboratory Science, Microbiology and Immunology, Infectious Disease, Medicine
Series:: Advances in Molecular and Cellular Microbiology (4)

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Susceptibility to Infectious Diseases
Edited by Richard Bellamy
Online ISBN: 9780511546235

Book DOI: https://doi.org/10.1017/CBO9780511546235
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In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.

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Susceptibility to Infectious Diseases

The Importance of Host Genetics

This Book has been cited by the following publications. This list is generated based on data provided by Crossref.

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Contents

Frontmatter
pp i-v

Contents
pp vi-vii

Contributors
pp viii-xv

1 - Introduction
pp 1-6

2 - Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections
pp 7-44

3 - The diverse genetic basis of immunodeficiencies
pp 45-76

4 - Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases
pp 77-116

5 - The cystic fibrosis transmembrane conductance regulator
pp 117-138

6 - The influence of inherited traits on malaria infection
pp 139-184

7 - Polymorphic chemokine receptor and ligand genes in HIV infection
pp 185-220

8 - NRAMP 1 and resistance to intracellular pathogens
pp 221-258

9 - The interleukin-12/interferon-γ loop is required for protective immunity to experimental and natural infections by Mycobacterium
pp 259-278

10 - Mannose-binding lectin deficiency and susceptibility to infectious disease
pp 279-308

11 - Blood group phenotypes and infectious diseases
pp 309-336

12 - Genetics of human susceptibility to infection and hepatic disease caused by schistosomes
pp 337-360

13 - Genetic susceptibility to prion diseases
pp 361-392

Index
pp 393-398

Plate section
pp 399-406

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Susceptibility to Infectious Diseases

The Importance of Host Genetics

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