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Chapter 18 - Leukemia: Acute and Chronic

Published online by Cambridge University Press:  23 October 2024

By
Sai Prasad Desikan ,
Sara Bresser  and
Alessandra Ferrajoli
Edited by
Laurie J. Mckenzie  and
Denise R. Nebgen
Laurie J. Mckenzie
Affiliation:
University of Texas MD Anderson Cancer Center, Houston
Denise R. Nebgen
Affiliation:
University of Texas MD Anderson Cancer Center, Houston
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Summary

Leukemias represent a range of bone marrow disorders that are broadly differentiated into acute and chronic. Acute leukemias, characterized by the proliferation of immature blood cells (blasts) and defined by peripheral blood or bone marrow blast percentage of 20 percent or more, are aggressive hematologic malignancies that are universally fatal without treatment. Chronic leukemias are mature leukemias with differentiated cells. Obstetric and gynecologic complications pose significant risk to the patient. Knowledge regarding uterine bleeding, fertility planning, and the management of the pregnant patient with leukemia are necessary in order to appropriately address these patients. In this chapter, we briefly review both acute and chronic leukemias, epidemiology, diagnosis and management, obstetric and gynecologic complications, teratogenicity of chemotherapies utilized in the treatment of each leukemia and finally detail our approach to the management of these patients.

Keywords

Acute Myeloid Leukemia (AML)Acute Lymphoblastic Leukemia (ALL)PregnancyAcute Uterine Bleeding (AUB)Chemotherapy Chronic lymphocytic leukemia (CLL)lymphadenopathyleukocytosisanemiasplenomegalyactive surveillanceBruton’s tyrosine kinase (BTK) inhibitorsChronic Myeloid Leukemia (CML)Philadelphia ChromosomeTyrosine Kinase Inhibitors (TKI)
Type
Chapter
Information
Caring for the Female Cancer Patient
Gynecologic Considerations
 , pp. 304 - 330
Publisher: Cambridge University Press
Print publication year: 2024

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