This chapter considers the uses of sublime blockage for science. The sublime was, on the one hand, a prod for precision and, on the other hand, a nod to skepticism and mystery, potentially ennobling an otherwise mechanical science. The chapter shows how astronomers, biologists, chemists, electricians, and natural historians and neurologists exploited sublime blockage either to elevate science above crude mechanism or butchery or to engage in skepticism so that it could arguably further scientific research. Such engagement with blockage paved the way for Franz Anton Mesmer’s quackery along with Benjamin Franklin’s efforts to defeat it, but quackery proved to be a more robust foe than anticipated.